Next Article in Journal
Ethyl Acetate Abatement on Copper Catalysts Supported on Ceria Doped with Rare Earth Oxides
Next Article in Special Issue
Hydrazino-methoxy-1,3,5-triazine Derivatives’ Excellent Corrosion Organic Inhibitors of Steel in Acidic Chloride Solution
Previous Article in Journal
MASM, a Matrine Derivative, Offers Radioprotection by Modulating Lethal Total-Body Irradiation-Induced Multiple Signaling Pathways in Wistar Rats
Previous Article in Special Issue
Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(5), 638; doi:10.3390/molecules21050638

A Convenient Synthesis of 3,7′-Bisindole Derivatives

1
Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
2
Guangdong Goodscend Pharm. Sci &Tech. Co., Ltd., Shantou 650091, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Richard A. Bunce
Received: 15 March 2016 / Revised: 5 May 2016 / Accepted: 6 May 2016 / Published: 17 May 2016
(This article belongs to the Collection Heterocyclic Compounds)
View Full-Text   |   Download PDF [1127 KB, uploaded 17 May 2016]   |  

Abstract

An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7′-bisindole derivatives in moderate to good yields. View Full-Text
Keywords: 3,7′-bisindoles; Michael addition; condensation reaction; heterocyclic ketene aminals 3,7′-bisindoles; Michael addition; condensation reaction; heterocyclic ketene aminals
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liu, T.; Zhu, H.-Y.; Luo, D.-Y.; Yan, S.-J.; Lin, J. A Convenient Synthesis of 3,7′-Bisindole Derivatives. Molecules 2016, 21, 638.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top