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Molecules 2016, 21(5), 558; doi:10.3390/molecules21050558

A Novel Photosensitizer 31,131-phenylhydrazine -Mppa (BPHM) and Its in Vitro Photodynamic Therapy against HeLa Cells

Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025, China
These authors contributed equally to this work.
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Authors to whom correspondence should be addressed.
Academic Editors: Marino Resendiz and Scott Reed
Received: 6 February 2016 / Revised: 22 April 2016 / Accepted: 23 April 2016 / Published: 29 April 2016
(This article belongs to the Special Issue Photoactive Molecules)
View Full-Text   |   Download PDF [4297 KB, uploaded 29 April 2016]   |  

Abstract

Photodynamic therapy (PDT) has attracted widespread attention due to its potential in the treatment of various cancers. Porphyrinic pyropheophorbide-a (PPa) has been shown to be a potent photosensitizer in PDT experiments. In this paper, a C-31,131 bisphenylhydrazone modified methyl pyropheophorbide-a (BPHM) was designed and synthesized with the consideration that phenylhydrazone structure may extend absorption wavelength of methyl pyro-pheophorbide-a (Mppa), and make the photosensitizer potential in deep tumor treatment. The synthesis, spectral properties and in vitro photodynamic therapy (PDT) against human HeLa cervical cancer cell line was studied. Methyl thiazolyl tetrazolium (MTT) assay showed the title compound could achieve strong inhibition of cervical cancer cell viability under visible light (675 nm, 25 J/cm2). Cell uptake experiments were performed on HeLa cells. Morphological changes were examined and analyzed by fluorescent inverted microscope. In addition, the mechanism of the photochemical processes of PDT was investigated, which showed that the formation of singlet oxygen after treatment with PDT played a moderate important role. View Full-Text
Keywords: photodynamic therapy (PDT); BPHM; cell cytotoxicity photodynamic therapy (PDT); BPHM; cell cytotoxicity
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Li, W.; Tan, G.; Cheng, J.; Zhao, L.; Wang, Z.; Jin, Y. A Novel Photosensitizer 31,131-phenylhydrazine -Mppa (BPHM) and Its in Vitro Photodynamic Therapy against HeLa Cells. Molecules 2016, 21, 558.

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