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Molecules 2016, 21(4), 492; doi:10.3390/molecules21040492

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, URAC23, Faculté des Sciences, Université Mohammed V, B.P. 1014 Rabat, Maroc
Institut de Chimie de Nice, ICN UMR UNS CNRS 7272, Université Nice-Sophia Antipolis-Université Côte d’Azur, Parc Valrose, 06108 Nice Cedex 2, France
Department of Chemistry, Université Paris Descartes, Sorbonne Paris Cité, UFR des Sciences Pharmaceutiques, 4 avenue de l’Observatoire & UFR Biomédicale des Saints Pères, 45 rue des Saints Pères, Paris Fr-75006, France
Authors to whom correspondence should be addressed.
Academic Editor: Philippe Belmont
Received: 22 February 2016 / Revised: 31 March 2016 / Accepted: 5 April 2016 / Published: 14 April 2016
(This article belongs to the Collection Heterocyclic Compounds)


This review describes the formation of six-membered heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions. The review is divided according to the main heterocycle types in order of increasing complexity, starting with heterocyclic systems containing one, two and three heteroatoms and their fused analogues. Recent microwave applications are reviewed, with special focus on the chemistry of bioactive compounds. Selected examples from the 2006 to 2015 literature are discussed. View Full-Text
Keywords: microwave irradiation; bioactive molecules; cycloaddition; cyclocondensation; multicomponent reactions microwave irradiation; bioactive molecules; cycloaddition; cyclocondensation; multicomponent reactions

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Driowya, M.; Saber, A.; Marzag, H.; Demange, L.; Benhida, R.; Bougrin, K. Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues. Molecules 2016, 21, 492.

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