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Molecules 2016, 21(4), 434; doi:10.3390/molecules21040434

Labdane Diterpenes from the Fruits of Sinopodophyllum emodi

1,2,* , 1,2
,
1,2
,
1,2
,
1,2
,
3
and
3,*
1
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China
2
School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, Henan, China
3
School of Pharmacy, China Medical University, Shenyang 110122, Liaoning, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Quan-Bin Han and Jian-Xin Pu
Received: 3 March 2016 / Revised: 21 March 2016 / Accepted: 24 March 2016 / Published: 31 March 2016
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
View Full-Text   |   Download PDF [929 KB, uploaded 31 March 2016]   |  

Abstract

Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1–4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity. View Full-Text
Keywords: Sinopodophyllum emodi; labdane diterpene; cytotoxic activity Sinopodophyllum emodi; labdane diterpene; cytotoxic activity
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MDPI and ACS Style

Sun, Y.-J.; Gao, M.-L.; Zhang, Y.-L.; Wang, J.-M.; Wu, Y.; Wang, Y.; Liu, T. Labdane Diterpenes from the Fruits of Sinopodophyllum emodi. Molecules 2016, 21, 434.

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