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Molecules 2016, 21(4), 411; doi:10.3390/molecules21040411

Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay

1
Office of Research Innovation and Commercialization, University of Peshawar, Peshawar-25120, Pakistan
2
Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan
3
Department of Pharmacy, Kohat University of Science and Technology, Kohat 26000, Pakistan
4
Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
5
Department of Crop Science, Faculty of Agriculture, 43400 UPM Serdang, Selangor, Malaysia
6
Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54600, Pakistan
7
Department of Physics, University of Malakand, Khyber Pakhtunkhwa 18800, Pakistan
*
Authors to whom correspondence should be addressed.
Academic Editor: Alexandru Mihai Grumezescu
Received: 27 January 2016 / Revised: 9 March 2016 / Accepted: 18 March 2016 / Published: 25 March 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
View Full-Text   |   Download PDF [2188 KB, uploaded 25 March 2016]   |  

Abstract

The fluoroquinolone antibacterial drug ciprofloxacin (cip) has been used to cap metallic (silver and gold) nanoparticles by a robust one pot synthetic method under optimized conditions, using NaBH4 as a mild reducing agent. Metallic nanoparticles (MNPs) showed constancy against variations in pH, table salt (NaCl) solution, and heat. Capping with metal ions (Ag/Au-cip) has significant implications for the solubility, pharmacokinetics and bioavailability of fluoroquinolone molecules. The metallic nanoparticles were characterized by several techniques such as ultraviolet visible spectroscopy (UV), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) methods. The nanoparticles synthesized using silver and gold were subjected to energy dispersive X-ray tests in order to show their metallic composition. The NH moiety of the piperazine group capped the Ag/Au surfaces, as revealed by spectroscopic studies. The synthesized nanoparticles were also assessed for urease inhibition potential. Fascinatingly, both Ag-cip and Au-cip NPs exhibited significant urease enzyme inhibitory potential, with IC50 = 1.181 ± 0.02 µg/mL and 52.55 ± 2.3 µg/mL, compared to ciprofloxacin (IC50 = 82.95 ± 1.62 µg/mL). MNPs also exhibited significant antibacterial activity against selected bacterial strains. View Full-Text
Keywords: metallic nanoparticles; ciprofloxacin; urease enzyme inhibition; antibacterial activity metallic nanoparticles; ciprofloxacin; urease enzyme inhibition; antibacterial activity
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Nisar, M.; Khan, S.A.; Qayum, M.; Khan, A.; Farooq, U.; Jaafar, H.Z.; Zia-Ul-Haq, M.; Ali, R. Robust Synthesis of Ciprofloxacin-Capped Metallic Nanoparticles and Their Urease Inhibitory Assay. Molecules 2016, 21, 411.

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