Next Article in Journal
Fluidized Bed Membrane Reactors for Ultra Pure H2 Production—A Step forward towards Commercialization
Previous Article in Journal
Effects of Astaxanthin from Litopenaeus Vannamei on Carrageenan-Induced Edema and Pain Behavior in Mice
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(3), 383; doi:10.3390/molecules21030383

A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc

1
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China
2
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
3
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 17 February 2016 / Revised: 15 March 2016 / Accepted: 16 March 2016 / Published: 19 March 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [989 KB, uploaded 19 March 2016]   |  

Abstract

Zanthoxylum schinifolium Sieb. et Zucc. (Rutaceae), a dioecious shrub with hooked prickly branches, has been used as folk medicine for the treatment of the common cold, stomach ache, diarrhea, and jaundice in China, Korea, and Japan. In our phytochemical investigations on this genus, a new megastigmane sesquiterpenoid, which is referred to as schinifolenol A (1), was isolated from Z. schinifolium. The stereochemistry was characterized via the analyses of extensive spectra. The absolute configuration was established by the application of a modified Mosher’s experiment and assisted by a time-dependent density functional theory (TD-DFT) on calculated electronic circular dichroism (ECD). Bioactivity screenings showed that compound 1 exhibited a safe hypotoxicity and a better selectivity on anti-Kaposi’s sarcoma associated herpes virus (KSHV). View Full-Text
Keywords: zanthoxylum schinifolium; megastigmane; sesquiterpenoid; Kaposi’s sarcoma associated herpes virus zanthoxylum schinifolium; megastigmane; sesquiterpenoid; Kaposi’s sarcoma associated herpes virus
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hu, L.; Wang, K.; Wang, Z.; Liu, J.; Wang, K.; Zhang, J.; Luo, Z.; Xue, Y.; Zhang, Y.; Zhang, Y. A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc. Molecules 2016, 21, 383.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top