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Molecules 2016, 21(3), 383; doi:10.3390/molecules21030383
Article

A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc

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1,*  and 2,*
1 Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China 2 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China 3 Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
* Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 17 February 2016 / Revised: 15 March 2016 / Accepted: 16 March 2016 / Published: 19 March 2016
(This article belongs to the Section Natural Products)
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Abstract

Zanthoxylum schinifolium Sieb. et Zucc. (Rutaceae), a dioecious shrub with hooked prickly branches, has been used as folk medicine for the treatment of the common cold, stomach ache, diarrhea, and jaundice in China, Korea, and Japan. In our phytochemical investigations on this genus, a new megastigmane sesquiterpenoid, which is referred to as schinifolenol A (1), was isolated from Z. schinifolium. The stereochemistry was characterized via the analyses of extensive spectra. The absolute configuration was established by the application of a modified Mosher’s experiment and assisted by a time-dependent density functional theory (TD-DFT) on calculated electronic circular dichroism (ECD). Bioactivity screenings showed that compound 1 exhibited a safe hypotoxicity and a better selectivity on anti-Kaposi’s sarcoma associated herpes virus (KSHV).
Keywords: zanthoxylum schinifolium; megastigmane; sesquiterpenoid; Kaposi’s sarcoma associated herpes virus zanthoxylum schinifolium; megastigmane; sesquiterpenoid; Kaposi’s sarcoma associated herpes virus
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hu, L.; Wang, K.; Wang, Z.; Liu, J.; Wang, K.; Zhang, J.; Luo, Z.; Xue, Y.; Zhang, Y.; Zhang, Y. A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc. Molecules 2016, 21, 383.

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