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Molecules 2016, 21(3), 378; doi:10.3390/molecules21030378

Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker

1
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
2
Shenzhen Research Institute, Central South University, Shenzhen 518057, China
3
School of Basic Medical Science, Central South University, Changsha 410078, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 February 2016 / Revised: 4 March 2016 / Accepted: 14 March 2016 / Published: 18 March 2016
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Abstract

There are urgent demands for satisfactory antibacterial activity and mechanical properties of bone scaffolds. In this study, zinc oxide whisker (ZnOw) was introduced into calcium sulfate/bioglass scaffolds. Antimicrobial behavior was analyzed using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results showed that the scaffolds presented a strong antibacterial activity after introducing ZnOw, due to the antibacterial factors released from the degradation of ZnO. Moreover, ZnOw was also found to have a distinct reinforcing effect on mechanical properties. This was ascribed to whisker pull-out, crack bridging, crack deflection, crack branching and other toughening mechanisms. In addition, the cell culture experiments showed that the scaffolds with ZnOw had a good biocompatibility. View Full-Text
Keywords: zinc oxide whisker; antibacterial activity; mechanical property; biocompatibility; scaffolds zinc oxide whisker; antibacterial activity; mechanical property; biocompatibility; scaffolds
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Shuai, C.; Zhou, J.; Gao, D.; Gao, C.; Feng, P.; Peng, S. Functionalization of Calcium Sulfate/Bioglass Scaffolds with Zinc Oxide Whisker. Molecules 2016, 21, 378.

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