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Molecules 2016, 21(3), 326; doi:10.3390/molecules21030326

Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
Current Address: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia
Academic Editor: Wim Dehaen
Received: 30 January 2016 / Revised: 29 February 2016 / Accepted: 29 February 2016 / Published: 9 March 2016
(This article belongs to the Collection Heterocyclic Compounds)
View Full-Text   |   Download PDF [3531 KB, uploaded 9 March 2016]   |  

Abstract

A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microbes. The molecular docking of the bis-pyrrole derivatives was performed by the Molecular Operating Environment (MOE) program. View Full-Text
Keywords: bis-pyrrole; antibacterial activity; antifungal activity; hydrazonoyl halides; molecular docking bis-pyrrole; antibacterial activity; antifungal activity; hydrazonoyl halides; molecular docking
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kheder, N.A. Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives. Molecules 2016, 21, 326.

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