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Molecules 2016, 21(12), 1715; doi:10.3390/molecules21121715

Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
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Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 15 September 2016 / Revised: 26 November 2016 / Accepted: 6 December 2016 / Published: 20 December 2016
(This article belongs to the Special Issue Stimuli-Responsive Biomaterials in Biomedical Applications)
View Full-Text   |   Download PDF [1852 KB, uploaded 20 December 2016]   |  

Abstract

Benefiting from the development of nanotechnology, drug delivery systems (DDSs) with stimuli-responsive controlled release function show great potential in clinical anti-tumor applications. By using a DDS, the harsh side effects of traditional anti-cancer drug treatments and damage to normal tissues and organs can be avoided to the greatest extent. An ideal DDS must firstly meet bio-safety standards and secondarily the efficiency-related demands of a large drug payload and controlled release function. This review highlights recent research progress on DDSs with stimuli-responsive characteristics. The first section briefly reviews the nanoscale scaffolds of DDSs, including mesoporous nanoparticles, polymers, metal-organic frameworks (MOFs), quantum dots (QDs) and carbon nanotubes (CNTs). The second section presents the main types of stimuli-responsive mechanisms and classifies these into two categories: intrinsic (pH, redox state, biomolecules) and extrinsic (temperature, light irradiation, magnetic field and ultrasound) ones. Clinical applications of DDS, future challenges and perspectives are also mentioned. View Full-Text
Keywords: drug delivery system; stimuli response; nanotechnology; anti-tumor treatment drug delivery system; stimuli response; nanotechnology; anti-tumor treatment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ding, C.; Tong, L.; Feng, J.; Fu, J. Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment. Molecules 2016, 21, 1715.

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