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Molecules 2016, 21(12), 1702; doi:10.3390/molecules21121702

A Review on Phytochemistry and Pharmacology of Cortex Periplocae

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1
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2
Tianjin Key Laboratory of Phytochemistry and Pharmaceutical Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
3
College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China
4
Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 November 2016 / Revised: 30 November 2016 / Accepted: 1 December 2016 / Published: 10 December 2016
View Full-Text   |   Download PDF [1466 KB, uploaded 10 December 2016]   |  

Abstract

Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities of Cortex Periplocae have been conducted recently. Meanwhile, the adverse reaction of Cortex Periplocae is not a negligible problem in clinic. In this article, we reviewed a series of articles and summarized the recent studies of Cortex Periplocae in the areas of phytochemistry and pharmacology. More than 100 constituents have been isolated and identified from Cortex Periplocae, including steroids, cardiac glycosides, terpenoids, and fatty acid compounds. The crude extracts of Cortex Periplocae and its active compounds exhibit various biological activities, such as cardiotonic effect, anticancer action, and anti-inflammatory effect. This paper aims to provide an overall review on the bioactive ingredients, pharmacological effect, and toxicity of this plant. Furthermore, this review suggests investigating and developing new clinical usages according to the above pharmacological effects. View Full-Text
Keywords: Cortex Periplocae; traditional Chinese medicines; periplocin; phytochemistry; biological activities Cortex Periplocae; traditional Chinese medicines; periplocin; phytochemistry; biological activities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, Y.; Li, J.; Zhou, K.; He, J.; Cao, J.; An, M.; Chang, Y.-X. A Review on Phytochemistry and Pharmacology of Cortex Periplocae. Molecules 2016, 21, 1702.

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