Next Article in Journal
Carbon Nanodots as Peroxidase Nanozymes for Biosensing
Next Article in Special Issue
Extraction and Quantification of Bioactive Tyrian Purple Precursors: A Comparative and Validation Study from the Hypobranchial Gland of a Muricid Dicathais orbita
Previous Article in Journal
Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects
Previous Article in Special Issue
Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(12), 1665; doi:10.3390/molecules21121665

Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica

1
Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China
2
Department of Plant Pathology, China Agricultural University, Haidian District, Beijing 100193, China
3
State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center of Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Wink
Received: 26 October 2016 / Revised: 23 November 2016 / Accepted: 29 November 2016 / Published: 2 December 2016
(This article belongs to the Special Issue Diversity of Alkaloids)
View Full-Text   |   Download PDF [558 KB, uploaded 2 December 2016]   |  

Abstract

A new pyrrolidine alkaloid named (Z)-3-(4-hydroxybenzylidene)-4-(4-hydroxyphenyl)-1-methylpyrrolidin-2-one was isolated from the ethanol extract of the root barks of Orixa japonica. The structure of the new alkaloid was elucidated on the basis of NMR and MS analysis. The compound exhibited larvicidal activity against the fourth instar larvae of Aedes aegypti (LC50 = 232.09 μg/mL), Anopheles sinensis (LC50 = 49.91 μg/mL), and Culex pipiens pallens (LC50 = 161.10 μg/mL). The new alkaloid also possessed nematicidal activity against Bursaphelenchus xylophilus (LC50 = 391.50 μg/mL) and Meloidogynein congnita (LC50 = 134.51 μg/mL). The results indicate that the crude ethanol extract of O. japonica root barks and its isolated pyrrolidine alkaloid have potential for development into natural larvicides and nematicides. View Full-Text
Keywords: Orixa japonica; mosquito; pyrrolidine alkaloid; larvicidal activity; nematicidal activity Orixa japonica; mosquito; pyrrolidine alkaloid; larvicidal activity; nematicidal activity
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liu, X.C.; Lai, D.; Liu, Q.Z.; Zhou, L.; Liu, Q.; Liu, Z.L. Bioactivities of a New Pyrrolidine Alkaloid from the Root Barks of Orixa japonica. Molecules 2016, 21, 1665.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top