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Molecules 2016, 21(11), 1533; doi:10.3390/molecules21111533

Antiproliferative, Cytotoxic, and Apoptotic Activity of Steroidal Oximes in Cervicouterine Cell Lines

1
Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230 Ciudad de México, Mexico
2
Laboratorio de Investigación, Jardín Botánico Universitario, Benemérita Universidad Autónoma de Puebla, 72570 Puebla, Pue., Mexico
3
Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de México, 04510 Ciudad de México, Mexico
4
Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510 Ciudad de México, Mexico
5
Centro de Investigación UNAM-UABJO, 68120 Oaxaca, Oax., Mexico
6
Departamento de Física Aplicada, Centro de Investigación y de Estudios Avanzados—Unidad Mérida, km 6 Antigua Carretera a Progreso, Cordemex, 97310 Mérida, Yuc., Mexico
7
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, 72570 Puebla, Pue., Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Margaret Brimble
Received: 17 September 2016 / Revised: 4 November 2016 / Accepted: 7 November 2016 / Published: 14 November 2016
(This article belongs to the Special Issue Women in Organic Chemistry)
View Full-Text   |   Download PDF [5398 KB, uploaded 14 November 2016]   |  

Abstract

Steroidal sapogenins have shown antiproliferative effects against several tumor cell lines; and their effects on human cancer cells are currently under study. Changes in the functionality on the steroidal structure make it possible to modify the biological activity of compounds. Herein, we report the synthesis and in vitro antitumor activity of two steroidal oxime compounds on cervical cancer cells. These derivatives were synthesized from the steroidal sapogenin diosgenin in good yields. The in vitro assays show that the steroidal oximes show significant antiproliferative activity compared to the one observed for diosgenin. Cell proliferation, cell death, and the cytotoxic effects were determined in both cervical cancer cells and human lymphocytes. The cancer cells showed apoptotic morphology and an increased presence of active caspase-3, providing the notion of a death pathway in the cell. Significantly, the steroidal oximes did not exert a cytotoxic effect on lymphocytes. View Full-Text
Keywords: steroidal oximes; 23-acetyldiosgenin; (25R)-spirost-4-en-3,6-dione; apoptosis; antiproliferative activity steroidal oximes; 23-acetyldiosgenin; (25R)-spirost-4-en-3,6-dione; apoptosis; antiproliferative activity
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MDPI and ACS Style

Sánchez-Sánchez, L.; Hernández-Linares, M.G.; Escobar, M.L.; López-Muñoz, H.; Zenteno, E.; Fernández-Herrera, M.A.; Guerrero-Luna, G.; Carrasco-Carballo, A.; Sandoval-Ramírez, J. Antiproliferative, Cytotoxic, and Apoptotic Activity of Steroidal Oximes in Cervicouterine Cell Lines. Molecules 2016, 21, 1533.

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