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Molecules 2016, 21(11), 1532; doi:10.3390/molecules21111532

One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents

1
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, Abha 61441, Saudi Arabia
3
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Panayiotis A. Koutentis
Received: 11 October 2016 / Revised: 5 November 2016 / Accepted: 9 November 2016 / Published: 15 November 2016
(This article belongs to the Special Issue Sulfur-Nitrogen Heteroaromatics)
View Full-Text   |   Download PDF [2693 KB, uploaded 15 November 2016]   |  

Abstract

A novel series of bis(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between bis-hydrazonoyl chloride 1 and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the bis-thiadiazole derivatives 5c,d, 7b,c and 9c had higher antitumor activity than the standard drug Imatinib. View Full-Text
Keywords: bis-hydrazonoyl chlorides; bis(1,3,4-thiadiazole); anticancer activity; methyl arylidene dithiocarbamate; dipolar cycloaddition reaction bis-hydrazonoyl chlorides; bis(1,3,4-thiadiazole); anticancer activity; methyl arylidene dithiocarbamate; dipolar cycloaddition reaction
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Gomha, S.M.; Kheder, N.A.; Abdelhamid, A.O.; Mabkhot, Y.N. One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents. Molecules 2016, 21, 1532.

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