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Molecules 2016, 21(11), 1481; doi:10.3390/molecules21111481

Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities

1
Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China
2
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 17 September 2016 / Revised: 2 November 2016 / Accepted: 4 November 2016 / Published: 7 November 2016
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Abstract

One new pentacyclic triterpenoid, 3β-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3α-ol (2), fernenol (3), and fern-7-en-3β-ol (4) were isolated from the petroleum ether phase of the ethanolic extract of Ainsliaea yunnanensis Franch. Their structures were established by spectroscopic methods including 1-D and 2-D NMR, and MS experiments. Compounds 1, 2, 3, and 4 showed significant selective cytotoxicity against human acute monocytic leukemia cell line (THP-1) with IC50 values of 5.12 μM, 1.78 μM, 1.74 μM, and 1.75 μΜ, respectively. Compound 1 also showed an anti-inflammatory effect through the inhibition of the activity of NF-κB by blocking the nuclear translocation of p65. View Full-Text
Keywords: Ainsliaea yunnanensis; triterpenoids; NMR; structures; activity Ainsliaea yunnanensis; triterpenoids; NMR; structures; activity
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Li, J.; Zhang, B.; Liu, H.; Zhang, X.; Shang, X.; Zhao, C. Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities. Molecules 2016, 21, 1481.

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