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Molecules 2016, 21(11), 1461; doi:10.3390/molecules21111461

Chemical Constituents of Muehlenbeckia tamnifolia (Kunth) Meisn (Polygonaceae) and Its In Vitro α-Amilase and α-Glucosidase Inhibitory Activities

1
Departamento de Química, Universidad Técnica Particular de Loja, Loja 1101608, Ecuador
2
Facultad de Farmacia, Universidad Central de Venezuela, Caracas 1040, Venezuela
3
Prometeo Project Researcher, SENESCYT, Quito 170516, Ecuador
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 13 September 2016 / Revised: 26 October 2016 / Accepted: 28 October 2016 / Published: 2 November 2016
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Abstract

The phytochemical investigation of Muehlenbeckia tamnifolia, collected in Loja-Ecuador, led to the isolation of nine known compounds identified as: lupeol acetate (1); cis-p-coumaric acid (2); lupeol (3); β-sitosterol (4) trans-p-coumaric acid (5); linoleic acid (6) (+)-catechin (7); afzelin (8) and quercitrin (9). The structures of the isolated compounds were determined based on analysis of NMR and MS data, as well as comparison with the literature. The hypoglycemic activity of crude extracts and isolated compounds was assessed by the ability to inhibit α-amylase and α-glucosidase enzymes. The hexane extract showed weak inhibitory activity on α-amylase, with an IC50 value of 625 µg·mL−1, while the other extracts and isolated compounds were inactive at the maximum dose tested. The results on α-glucosidase showed more favorable effects; the hexanic and methanolic extracts exhibited a strong inhibitory activity with IC50 values of 48.22 µg·mL−1 and 19.22 µg·mL−1, respectively. Four of the nine isolated compounds exhibited strong inhibitory activity with IC50 values below 8 µM, much higher than acarbose (377 uM). Linoleic acid was the most potent compound (IC50 = 0.42 µM) followed by afzelin, (+)-catechin and quercitrin. View Full-Text
Keywords: Muehlenbeckia tamnifolia; α-glucosidase inhibition; α-amilase inhibition; linoleic acid Muehlenbeckia tamnifolia; α-glucosidase inhibition; α-amilase inhibition; linoleic acid
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MDPI and ACS Style

Torres-Naranjo, M.; Suárez, A.; Gilardoni, G.; Cartuche, L.; Flores, P.; Morocho, V. Chemical Constituents of Muehlenbeckia tamnifolia (Kunth) Meisn (Polygonaceae) and Its In Vitro α-Amilase and α-Glucosidase Inhibitory Activities. Molecules 2016, 21, 1461.

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