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Molecules 2016, 21(11), 1442; doi:10.3390/molecules21111442

Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress

1
Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico
2
Consejo Nacional de Ciencia y Tecnología (CONACYT)—Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco No. 186, Col. Vicentina, Iztapalapa, 09340 Mexico City, Mexico
3
Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Luciano Saso, László Dux, Grzegorz Wegrzyn and Tamás Csont
Received: 3 October 2016 / Revised: 17 October 2016 / Accepted: 24 October 2016 / Published: 29 October 2016
(This article belongs to the Special Issue Chemistry and Pharmacology of Modulators of Oxidative Stress)
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Abstract

There is currently no doubt about the serious threat that oxidative stress (OS) poses to human health. Therefore, a crucial strategy to maintain a good health status is to identify molecules capable of offering protection against OS through chemical routes. Based on the known efficiency of the phenolic and melatonin (MLT) families of compounds as antioxidants, it is logical to assume that phenolic MLT-related compounds should be (at least) equally efficient. Unfortunately, they have been less investigated than phenols, MLT and its non-phenolic metabolites in this context. The evidence reviewed here strongly suggests that MLT phenolic derivatives can act as both primary and secondary antioxidants, exerting their protection through diverse chemical routes. They all seem to be better free radical scavengers than MLT and Trolox, while some of them also surpass ascorbic acid and resveratrol. However, there are still many aspects that deserve further investigations for this kind of compounds. View Full-Text
Keywords: free radicals; scavenging activity; metal chelation; kinetics; reaction mechanisms; trends in activity free radicals; scavenging activity; metal chelation; kinetics; reaction mechanisms; trends in activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Galano, A.; Castañeda-Arriaga, R.; Pérez-González, A.; Tan, D.-X.; Reiter, R.J. Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress. Molecules 2016, 21, 1442.

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