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Molecules 2016, 21(11), 1433; doi:10.3390/molecules21111433

Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique

1
Institute of Medicinal Plant Development (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
2
Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medicinal Sciences & Peking Union Medical College (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Haikou 570311, China
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 26 August 2016 / Revised: 2 October 2016 / Accepted: 22 October 2016 / Published: 27 October 2016
(This article belongs to the Section Natural Products)
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Abstract

Four new 2-(2-phenylethyl)chromone derivatives (14) were isolated from the EtOH extract of Chinese agarwood produced via the whole-tree agarwood-inducing technique, coming from Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae). Their structures were elucidated by extensive spectroscopic methods, such as UV, IR, MS, 1D as well as 2D NMR. All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Compound 1 exhibited significant inhibitory activity with an IC50 value of 4.6 μM. View Full-Text
Keywords: Chinese agarwood; 2-(2-phenylethyl)chromone derivatives; Aquilaria sinensis; whole-tree agarwood-inducing technique; anti-inflammatory Chinese agarwood; 2-(2-phenylethyl)chromone derivatives; Aquilaria sinensis; whole-tree agarwood-inducing technique; anti-inflammatory
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, Y.-Y.; Chen, D.-L.; Wei, J.-H.; Feng, J.; Zhang, Z.; Yang, Y.; Zheng, W. Four New 2-(2-Phenylethyl)chromone Derivatives from Chinese Agarwood Produced via the Whole-Tree Agarwood-Inducing Technique. Molecules 2016, 21, 1433.

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