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Molecules 2016, 21(10), 1402; doi:10.3390/molecules21101402

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

1
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China
2
School of Basic Medicine, Beijing University of Chinese Medicine, Beijing 100102, China
3
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 30 September 2016 / Revised: 30 September 2016 / Accepted: 12 October 2016 / Published: 24 October 2016
(This article belongs to the Section Medicinal Chemistry)

Abstract

Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3′,6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM), presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the family Polygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds. View Full-Text
Keywords: cinnamic acid sugar ester derivatives; phytochemistry; pharmacological activity; traditional Chinese medicine cinnamic acid sugar ester derivatives; phytochemistry; pharmacological activity; traditional Chinese medicine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tian, Y.; Liu, W.; Lu, Y.; Wang, Y.; Chen, X.; Bai, S.; Zhao, Y.; He, T.; Lao, F.; Shang, Y.; Guo, Y.; She, G. Naturally Occurring Cinnamic Acid Sugar Ester Derivatives. Molecules 2016, 21, 1402.

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