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Molecules 2016, 21(10), 1375; doi:10.3390/molecules21101375

Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site

1
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
2
School of Environment, Guangzhou Key Laboratory of Environmental Exposure and Health and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Wei Li
Received: 10 September 2016 / Revised: 10 October 2016 / Accepted: 11 October 2016 / Published: 15 October 2016
(This article belongs to the Special Issue Tubulin Inhibitors)
View Full-Text   |   Download PDF [6545 KB, uploaded 15 October 2016]   |  

Abstract

Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side-effects, and generally poor bioavailability. Thus, there is a constant need to search for novel tubulin inhibitors that can overcome these limitations. Natural product and privileged structures targeting tubulin have promoted the discovery and optimization of tubulin inhibitors. This review will focus on novel tubulin inhibitors derived from natural products and privileged structures targeting the colchicine binding site on tubulin. View Full-Text
Keywords: tubulin inhibitors; microtubule dynamics; antimitotic; multidrug resistance tubulin inhibitors; microtubule dynamics; antimitotic; multidrug resistance
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Dong, M.; Liu, F.; Zhou, H.; Zhai, S.; Yan, B. Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site. Molecules 2016, 21, 1375.

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