Protective Effect of the Plant Extracts of Erythroxylum sp. against Toxic Effects Induced by the Venom of Lachesis muta Snake
AbstractSnake venoms are composed of a complex mixture of active proteins that induce toxic effects, such as edema, hemorrhage, and death. Lachesis muta has the highest lethality indices in Brazil. In most cases, antivenom fails to neutralize local effects, leading to disabilities in victims. Thus, alternative treatments are under investigation, and plant extracts are promising candidates. The objective of this work was to investigate the ability of crude extracts, fractions, or isolated products of Erythroxylum ovalifolium and Erythroxylum subsessile to neutralize some toxic effects of L. muta venom. All samples were mixed with L. muta venom, then in vivo (hemorrhage and edema) and in vitro (proteolysis, coagulation, and hemolysis) assays were performed. Overall, crude extracts or fractions of Erythroxylum spp. inhibited (20%–100%) toxic effects of the venom, but products achieved an inhibition of 4%–30%. However, when venom was injected into mice before the plant extracts, hemorrhage and edema were not inhibited by the samples. On the other hand, an inhibition of 5%–40% was obtained when extracts or products were given before venom injection. These results indicate that the extracts or products of Erythroxylum spp. could be a promising source of molecules able to treat local toxic effects of envenomation by L. muta venom, aiding in the development of new strategies for antivenom treatment. View Full-Text
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Coriolano de Oliveira, E.; Alves Soares Cruz, R.; de Mello Amorim, N.; Guerra Santos, M.; Carlos Simas Pereira Junior, L.; Flores Sanchez, E.O.; Pinho Fernandes, C.; Garrett, R.; Machado Rocha, L.; Lopes Fuly, A. Protective Effect of the Plant Extracts of Erythroxylum sp. against Toxic Effects Induced by the Venom of Lachesis muta Snake. Molecules 2016, 21, 1350.
Coriolano de Oliveira E, Alves Soares Cruz R, de Mello Amorim N, Guerra Santos M, Carlos Simas Pereira Junior L, Flores Sanchez EO, Pinho Fernandes C, Garrett R, Machado Rocha L, Lopes Fuly A. Protective Effect of the Plant Extracts of Erythroxylum sp. against Toxic Effects Induced by the Venom of Lachesis muta Snake. Molecules. 2016; 21(10):1350.Chicago/Turabian Style
Coriolano de Oliveira, Eduardo; Alves Soares Cruz, Rodrigo; de Mello Amorim, Nayanna; Guerra Santos, Marcelo; Carlos Simas Pereira Junior, Luiz; Flores Sanchez, Eladio O.; Pinho Fernandes, Caio; Garrett, Rafael; Machado Rocha, Leandro; Lopes Fuly, André. 2016. "Protective Effect of the Plant Extracts of Erythroxylum sp. against Toxic Effects Induced by the Venom of Lachesis muta Snake." Molecules 21, no. 10: 1350.
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