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Molecules 2016, 21(10), 1336; doi:10.3390/molecules21101336

The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease

1,2
,
1,2,* and 1,2
1
Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China
2
Institute of Metabolic Disease, Fudan University, Shanghai 200032, China
*
Author to whom correspondence should be addressed.
Academic Editors: Dong Kug Choi and Palanivel Ganesan
Received: 8 August 2016 / Revised: 26 September 2016 / Accepted: 29 September 2016 / Published: 14 October 2016
(This article belongs to the Special Issue Natural Products and Chronic Diseases)
View Full-Text   |   Download PDF [1707 KB, uploaded 14 October 2016]   |  

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a globally observed metabolic disease with high prevalence both in adults and children. However, there is no efficient medication available yet. Increased evidence indicates that berberine (BBR), a natural plant product, has beneficial effects on NAFLD, though the mechanisms are not completely known. In this review, we briefly summarize the pathogenesis of NAFLD and factors that influence the progression of NAFLD, and focus on the potential mechanisms of BBR in the treatment of NAFLD. Increase of insulin sensitivity, regulation of adenosine monophosphate-activated protein kinase (AMPK) pathway, improvement of mitochondrial function, alleviation of oxidative stress, LDLR mRNA stabilization, and regulation of gut microenvironment are the major targets of BBR in the treatment of NAFLD. Additionally, reduction of proprotein convertase subtilisin/kexin 9 (PCSK9) expression and DNA methylation are also involved in pharmacological mechanisms of berberine in the treatment of NAFLD. The immunologic mechanism of BBR in the treatment of NAFLD, development of berberine derivative, drug combinations, delivery routes, and drug dose can be considered in the future research. View Full-Text
Keywords: berberine; nonalcoholic fatty liver disease; mechanism; insulin resistance; adenosine monophosphate-activated protein kinase berberine; nonalcoholic fatty liver disease; mechanism; insulin resistance; adenosine monophosphate-activated protein kinase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhu, X.; Bian, H.; Gao, X. The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease. Molecules 2016, 21, 1336.

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