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Molecules 2016, 21(10), 1326; doi:10.3390/molecules21101326

Saponins from Chinese Medicines as Anticancer Agents

1
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
2
College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
*
Authors to whom correspondence should be addressed.
Received: 15 August 2016 / Accepted: 30 September 2016 / Published: 5 October 2016
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Abstract

Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo anticancer effects, such as anti-proliferation, anti-metastasis, anti-angiogenesis, anti-multidrug resistance, and autophagy regulation actions. In addition, related signaling pathways and target proteins involved in the anticancer effects of saponins are also summarized in this work. View Full-Text
Keywords: triterpenoid saponins; steroid saponins; mechanism; target; cancer triterpenoid saponins; steroid saponins; mechanism; target; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xu, X.-H.; Li, T.; Fong, C.M.V.; Chen, X.; Chen, X.-J.; Wang, Y.-T.; Huang, M.-Q.; Lu, J.-J. Saponins from Chinese Medicines as Anticancer Agents. Molecules 2016, 21, 1326.

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