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Molecules 2016, 21(10), 1305; doi:10.3390/molecules21101305

Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate on Obesity

1
Faculty of Education, Art and Science, Yamagata University, Yamagata 990-8560, Japan
2
Tea Science Center, University of Shizuoka, Shizuoka 422-8526, Japan
3
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Min-Hsiung Pan, Filomena Conforti and Derek J. McPhee
Received: 15 August 2016 / Revised: 22 September 2016 / Accepted: 24 September 2016 / Published: 29 September 2016
(This article belongs to the Special Issue Natural Products in Anti-Obesity Therapy)
View Full-Text   |   Download PDF [743 KB, uploaded 29 September 2016]   |  

Abstract

Green tea has been shown to have beneficial effects against cancer, obesity, atherosclerosis, diabetes, bacterial and viral infections, and dental caries. The catechin (−)-epigallocatechin-3-gallate (EGCG) has shown the highest biological activity among green tea catechins (GTCs) in most of the studies. While several epidemiological studies have shown the beneficial effects of tea and GTCs on obesity, some studies have failed to do this. In addition, a large number of interventional clinical studies have shown these favorable effects, and cellular and animal experiments have supported those findings, and revealed the underlying anti-obesity mechanisms. One of the mechanisms is enhanced cellular production of reactive oxygen species, which is mediated through the pro-oxidant action of EGCG, leading to the activation of adenosine monophosphate-activated protein kinase, which suppresses gene and protein expression of enzymes and transcription factors involved in adipogenesis and lipogenesis, and stimulates those involved in lipolysis. Recently, scientific evidence supporting the beneficial anti-obesity effects of green tea and GTCs has been increasing. However, future investigations are still required to clarify the reasons for the inconsistent results reported in the human studies; to achieve this, careful adjustment of confounding factors will be required. View Full-Text
Keywords: green tea; catechin; obesity; adipogenesis; lipogenesis; lipolysis; AMPK green tea; catechin; obesity; adipogenesis; lipogenesis; lipolysis; AMPK
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Suzuki, T.; Pervin, M.; Goto, S.; Isemura, M.; Nakamura, Y. Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate on Obesity. Molecules 2016, 21, 1305.

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