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Molecules 2016, 21(10), 1299; doi:10.3390/molecules21101299

New Diphenol and Isocoumarins from the Aerial Part of Lawsonia inermis and Their Inhibitory Activities against NO Production

1
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
2
Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan
3
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
4
Agricultural Biotechnology Center, National Chung-Hsing University, Taichung 402, Taiwan
5
Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
6
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
7
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
8
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
9
Department of Biotechnology, Asia University, Taichung 413, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editors: Nancy D. Turner and Isabel C. F. R. Ferreira
Received: 17 August 2016 / Revised: 22 September 2016 / Accepted: 23 September 2016 / Published: 28 September 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [1334 KB, uploaded 28 September 2016]   |  

Abstract

Lawsonia inermis Linn (Lythraceae), also known as henna, is a small shrub or tree distributed throughout Taiwan’s Lanyu Island, in North Africa, and in Australia. Its leaves are used as a folk medicine for the treatment of external hemorrhage and fingernail abscesses. Investigation of the ethyl acetate (EtOAc)-soluble fractions from methanol extract of the aerial part of Lawsonia inermis has led to the isolation of a new diphenol, (Z)-4,4′-(prop-1-ene-1,3-diyl)diphenol (1), two new isocoumarin carbonates, inermiscarbonates A (2) and B (3), and six known compounds, 4′-hydroxyflavanone (4), apigenine (5), kampferol (6), luteolin (7), quercetin (8), and (-)-catechin (9). Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. Compounds 1 and 49 were evaluated for the inhibition of nitric oxide production in lipopolysaccharide (LPS)-stimulated product of nitrite in RAW 264.7 cells with IC50 values of 5.63, 15.72, 8.67, 6.67, 6.17, 7.61, and 14.52 μg/mL, respectively. View Full-Text
Keywords: Lawsonia inermis; henna; diphenol; isocoumarin; inhibitory activities against NO production Lawsonia inermis; henna; diphenol; isocoumarin; inhibitory activities against NO production
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MDPI and ACS Style

Yang, C.-S.; Huang, H.-C.; Wang, S.-Y.; Sung, P.-J.; Huang, G.-J.; Chen, J.-J.; Kuo, Y.-H. New Diphenol and Isocoumarins from the Aerial Part of Lawsonia inermis and Their Inhibitory Activities against NO Production. Molecules 2016, 21, 1299.

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