Next Article in Journal
Palladium-Catalyzed C–H Arylation of 1,2,3-Triazoles
Previous Article in Journal
Cyanidin-3-O-glucoside: Physical-Chemistry, Foodomics and Health Effects
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(10), 1256; doi:10.3390/molecules21101256

Bioactivity of a Novel Glycolipid Produced by a Halophilic Buttiauxella sp. and Improving Submerged Fermentation Using a Response Surface Method

1
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad 91775-1365, Iran
2
Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran 19839-4716, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 29 August 2016 / Revised: 13 September 2016 / Accepted: 15 September 2016 / Published: 22 September 2016
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [1761 KB, uploaded 22 September 2016]   |  

Abstract

An antimicrobial glycolipid biosurfactant (GBS), extracted and identified from a marine bacterium, was studied to inhibit pathogenic microorganisms. Production of the GBS was optimized using a statistical method, a response surface method (RSM) with a central composite design (CCD) for obtaining maximum yields on a cost-effective substrate, molasses. The GBS-producing bacterium was identified as Buttiauxella Species in terms of biochemical and molecular characteristics. This compound showed a desirable antimicrobial activity against some pathogens such as E. coli, Bacillus subtilis, Bacillus cereus, Candida albicans, Aspergilus niger, Salmonella enterica. The rheological studies described the stability of the GBS at high values in a range of pH (7–8), temperature (20–60) and salinity (0%–3%). The statistical optimization of GBS fermentation was found to be pH 7, temperature 33 °C, Peptone 1%, NaCl 1% and molasses 1%. The potency of the GBS as an effective antimicrobial agent provides evidence for its use against food and human pathogens. Moreover, favorable production of the GBS in the presence of molasses as a cheap substrate and the feasibility of pilot scale fermentation using an RSM method could expand its uses in food, pharmaceutical products and oil industries. View Full-Text
Keywords: glycolipid biosurfactant; antimicrobial activity; Buttiauxella; response surface method glycolipid biosurfactant; antimicrobial activity; Buttiauxella; response surface method
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Marzban, A.; Ebrahimipour, G.; Danesh, A. Bioactivity of a Novel Glycolipid Produced by a Halophilic Buttiauxella sp. and Improving Submerged Fermentation Using a Response Surface Method. Molecules 2016, 21, 1256.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top