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Molecules 2016, 21(1), 77; doi:10.3390/molecules21010077

The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice

1
Central Laboratory, The Second Clinical Hospital, Jilin University, Changchun 130041, China
2
Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun 130062, China
3
School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
4
Key Laboratory of Molecular Enzymology & Engineering, Ministry of Education, College of Life Science, Jilin University, Changchun 130012, China
5
Jilin Provincial Center for Disease Control and Prevention, Changchun 130062, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Norbert Latruffe
Received: 11 December 2015 / Revised: 4 January 2016 / Accepted: 7 January 2016 / Published: 11 January 2016
(This article belongs to the Special Issue Natural Products and Inflammation)
View Full-Text   |   Download PDF [2109 KB, uploaded 11 January 2016]   |  

Abstract

Acute respiratory distress syndrome (ARDS),which is inflammatory disorder of the lung, which is caused by pneumonia, aspiration of gastric contents, trauma and sepsis, results in widespread lung inflammation and increased pulmonary vascular permeability. Its pathogenesis is complicated and the mortality is high. Thus, there is a tremendous need for new therapies. We have reported that HJB-1, a 17-hydroxy-jolkinolide B derivative, exhibited strong anti-inflammatory effects in vitro. In this study, we investigated its impacts on LPS-induced ARDS mice. We found that HJB-1 significantly alleviated LPS-induced pulmonary histological alterations, inflammatory cells infiltration, lung edema, as well as the generation of inflammatory cytokines TNF-α, IL-1β and IL-6 in BALF. In addition, HJB-1 markedly suppressed LPS-induced IκB-α degradation, nuclear accumulation of NF-κB p65 subunit and MAPK phosphorylation. These results suggested that HJB-1 improved LPS-induced ARDS by suppressing LPS-induced NF-κB and MAPK activation. View Full-Text
Keywords: Acute respiratory distress syndrome (ARDS); NF-κB; MAPK; 17-hydroxy-jolkinolide B; edema Acute respiratory distress syndrome (ARDS); NF-κB; MAPK; 17-hydroxy-jolkinolide B; edema
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MDPI and ACS Style

Xu, X.; Liu, N.; Zhang, Y.-X.; Cao, J.; Wu, D.; Peng, Q.; Wang, H.-B.; Sun, W.-C. The Protective Effects of HJB-1, a Derivative of 17-Hydroxy-Jolkinolide B, on LPS-Induced Acute Distress Respiratory Syndrome Mice. Molecules 2016, 21, 77.

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