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Molecules 2016, 21(1), 58; doi:10.3390/molecules21010058

New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity

1
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
2
College of Pharmacy and Chemistry, Dali University, Dali 671000, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: John Beutler and Fernando Albericio
Received: 12 November 2015 / Revised: 25 December 2015 / Accepted: 29 December 2015 / Published: 5 January 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [747 KB, uploaded 5 January 2016]   |  

Abstract

Phytochemical investigation on the stems of C. tabularis led to the isolation of five new phragmalin-type limonoids and six known ones. The structures of the new compounds 15, named chukbularisins A–E, were elucidated by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparisons with published data. All the compounds were evaluated for in vitro α-glucosidase inhibitory activity. Compounds 2, 3, 4, 5, and 8 exhibited inhibitory activity against α-glucosidase with IC50 values of 0.06 ± 0.008, 0.04 ± 0.002, 0.52 ± 0.039, 1.09 ± 0.040, and 0.20 ± 0.057 mM, respectively (using acarbose as positive control, IC50 0.95 ± 0.092 mM). View Full-Text
Keywords: Chukrasia tabularis; Meliaceae; limonoid; α-Glucosidase inhibition activity Chukrasia tabularis; Meliaceae; limonoid; α-Glucosidase inhibition activity
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MDPI and ACS Style

Peng, J.-L.; Wang, J.; Kong, F.-D.; Liu, Z.-Q.; Wang, P.; Gai, C.-J.; Jiang, B.; Mei, W.-L.; Dai, H.-F. New Phragmalin-Type Limonoids from Chukrasia tabularis and Their α-Glucosidase Inhibitory Activity. Molecules 2016, 21, 58.

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