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Molecules 2016, 21(1), 34; doi:10.3390/molecules21010034

Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40

1
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
4
Laboratory of State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 2 November 2015 / Revised: 18 December 2015 / Accepted: 21 December 2015 / Published: 26 December 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [1615 KB, uploaded 26 December 2015]   |  

Abstract

Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge–derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (17) were determined by the extensive 1D- and 2D-NMR spectra, and HRESIMS spectrometry. All the compounds were tested for their antiviral (H1N1 and H3N2) activity. Compounds 2 and 3 showed significant activity against H3N2 with the prominent IC50 values of 6.2 ± 0.08 and 8.9 ± 0.3 μM, respectively. In addition, compound 2 also exhibited inhibitory activity against H1N1 with an IC50 value of 3.5 ± 1.3 μM. View Full-Text
Keywords: sponge-derived fungus; asteltoxins; antiviral (H1N1 and H3N2) activity sponge-derived fungus; asteltoxins; antiviral (H1N1 and H3N2) activity
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Tian, Y.-Q.; Lin, X.-P.; Wang, Z.; Zhou, X.-F.; Qin, X.-C.; Kaliyaperumal, K.; Zhang, T.-Y.; Tu, Z.-C.; Liu, Y. Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40. Molecules 2016, 21, 34.

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