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Molecules 2015, 20(8), 15192-15201; doi:10.3390/molecules200815192

A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa

1
School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
2
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
3
School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 June 2015 / Revised: 13 August 2015 / Accepted: 14 August 2015 / Published: 20 August 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1199 KB, uploaded 20 August 2015]   |  

Abstract

A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans AC (24) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 13 exhibited protective effects against DOX-induced cardiotoxicity. View Full-Text
Keywords: Rehmannia glutinosa; ionone glycoside; rhemaneolignans; the protective effects of cardiomyocytes Rehmannia glutinosa; ionone glycoside; rhemaneolignans; the protective effects of cardiomyocytes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, M.; Wang, X.; Zheng, X.; Wang, J.; Zhao, W.; Song, K.; Zhao, X.; Zhang, Y.; Kuang, H.; Feng, W. A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa. Molecules 2015, 20, 15192-15201.

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