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Molecules 2015, 20(8), 14451-14473; doi:10.3390/molecules200814451

Absorption-Enhancing Effects of Bile Salts

1
Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-33184, Iran
2
Department of Drug and Food Control, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-33184, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 June 2015 / Revised: 28 July 2015 / Accepted: 31 July 2015 / Published: 10 August 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [2307 KB, uploaded 14 August 2015]   |  

Abstract

Bile salts are ionic amphiphilic compounds with a steroid skeleton. Among the most important physiological properties of bile salts are lipid transport by solubilization and transport of some drugs through hydrophobic barriers. Bile salts have been extensively studied to enhance transepithelial permeability for different marker molecules and drugs. They readily agglomerate at concentrations above their critical micelle concentration (CMC). The mechanism of absorption enhancement by bile salts appears to be complex. The aim of the present article was to review bile salt structure and their application as absorption enhancers and the probable mechanism for increasing permeation based on previous studies. View Full-Text
Keywords: bile salts; drug delivery; absorption enhancers bile salts; drug delivery; absorption enhancers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Moghimipour, E.; Ameri, A.; Handali, S. Absorption-Enhancing Effects of Bile Salts. Molecules 2015, 20, 14451-14473.

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