Next Article in Journal
Qualitative and Quantitative Analysis of Major Triterpenoids in Alismatis Rhizoma by High Performance Liquid Chromatography/Diode-Array Detector/Quadrupole-Time-of-Flight Mass Spectrometry and Ultra-Performance Liquid Chromatography/Triple Quadrupole Mass Spectrometry
Previous Article in Journal
Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(8), 13941-13957; doi:10.3390/molecules200813941

Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives

1
Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education College of Agriculture, South China Agricultural University, Guangzhou 510642, China
2
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 15 July 2015 / Revised: 28 July 2015 / Accepted: 29 July 2015 / Published: 31 July 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1022 KB, uploaded 31 July 2015]   |  

Abstract

A series of β-Carboline derivatives were designed, synthesized, and evaluated for their fungicidal activities in this study. Several derivatives electively exhibited fungicidal activities against some fungi. Especially, compound F5 exhibited higher fungicidal activity against Rhizoctonia solani (53.35%) than commercial antiviral agent validamycin (36.4%); compound F16 exhibited high fungicidal activity against Oospora citriaurantii ex Persoon (43.28%). Some of the alkaloids and their derivatives (compounds F4 and F25) exhibited broad-spectrum fungicidal activity. Specifically, compound F4 exhibited excellent high broad-spectrum fungicidal activity in vitro, and the curative and protection activities against P. litchi in vivo reached 92.59% and 59.26%, respectively. The new derivative, F4, with optimized physicochemical properties, obviously exhibited higher activities both in vitro and in vivo; therefore, F4 may be used as a new lead structure for the development of fungicidal drugs. View Full-Text
Keywords: β-carboline; fungicidal activity; structure–activity relationship β-carboline; fungicidal activity; structure–activity relationship
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Li, Z.; Chen, S.; Zhu, S.; Luo, J.; Zhang, Y.; Weng, Q. Synthesis and Fungicidal Activity of β-Carboline Alkaloids and Their Derivatives. Molecules 2015, 20, 13941-13957.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top