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Molecules 2015, 20(7), 13281-13295; doi:10.3390/molecules200713281

The Antioxidant Activity and Their Major Antioxidant Compounds from Acanthopanax senticosus and A. koreanum

1
Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea
2
National Institute of Biological Resources, Incheon 404-708, Korea
3
STR Biotech Co., LTD, Gangwon 200-160, Korea
4
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA
These authors distributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 19 May 2015 / Revised: 25 June 2015 / Accepted: 15 July 2015 / Published: 22 July 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [1397 KB, uploaded 22 July 2015]   |  

Abstract

The antioxidant activity and chlorogenic acid and caffeic acid contents were investigated from different parts of Acanthopanax senticosus and A. koreanum. Antioxidant activity was assessed by various in vitro assays such as DPPH, ABTS, FRAP, reducing power assays and ORAC, and the chlorogenic acid and caffeic acid were validated by HPLC chromatography. Among the various extracts, the fruit extracts of A. senticosus and A. koreanum exhibited strongest antioxidant activities including ABTS, FRAP, reducing power and ORAC, however, strongest DPPH radical scavenging activity was observed from the leaf extract of A. senticosus. In addition, the antioxidant activities of various extracts were correlated with total phenolic and proanthocyanidin contents. The major phenolic contents from various parts of these plants observed that leaf extract of A. senticosus expressed higher levels of chlorogenic acid (14.86 mg/dry weigh g) and caffeic acid (3.09 mg/dry weigh g) than other parts. Therefore, these results suggest that the leaf of A. senticosus may be an excellent natural source for functional foods and pharmaceutical agents, and the validated method was useful for the quality control of A. senticosus. View Full-Text
Keywords: Acanthopanax senticosus; method validation; antioxidant activity; chlorogenic acid; caffeic acid Acanthopanax senticosus; method validation; antioxidant activity; chlorogenic acid; caffeic acid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kim, Y.-H.; Cho, M.L.; Kim, D.-B.; Shin, G.-H.; Lee, J.-H.; Lee, J.S.; Park, S.-O.; Lee, S.-J.; Shin, H.M.; Lee, O.-H. The Antioxidant Activity and Their Major Antioxidant Compounds from Acanthopanax senticosus and A. koreanum. Molecules 2015, 20, 13281-13295.

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