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Molecules 2015, 20(7), 12863-12879; doi:10.3390/molecules200712863

Dual Radiolabeling as a Technique to Track Nanocarriers: The Case of Gold Nanoparticles

1
DST/NWU Preclinical Drug Development Platform, Faculty of Health Sciences, Potchefstroom Campus, North-West University, Potchefstroom 2531, South Africa
2
Radiochemistry Department, South African Nuclear Energy Corporation (SOC) Ltd., P. O. Box 482, Pretoria 0001, South Africa
3
Laboratory for Electron Microscopy, Chemical Resources Beneficiation Group, Potchefstroom Campus, North-West University, Potchefstroom 2531, South Africa
4
Statistical Consultation Services, Potchefstroom Campus, North-West University, Potchefstroom 2531, South Africa
*
Author to whom correspondence should be addressed.
Academic Editor: Svend Borup Jensen
Received: 23 May 2015 / Revised: 22 June 2015 / Accepted: 10 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Preparation of Radiopharmaceuticals and Their Use in Drug Development)
View Full-Text   |   Download PDF [1872 KB, uploaded 16 July 2015]   |  

Abstract

Gold nanoparticles (AuNPs) have shown great potential for use in nanomedicine and nanotechnologies due to their ease of synthesis and functionalization. However, their apparent biocompatibility and biodistribution is still a matter of intense debate due to the lack of clear safety data. To investigate the biodistribution of AuNPs, monodisperse 14-nm dual-radiolabeled [14C]citrate-coated [198Au]AuNPs were synthesized and their physico-chemical characteristics compared to those of non-radiolabeled AuNPs synthesized by the same method. The dual-radiolabeled AuNPs were administered to rats by oral or intravenous routes. After 24 h, the amounts of Au core and citrate surface coating were quantified using gamma spectroscopy for 198Au and liquid scintillation for the 14C. The Au core and citrate surface coating had different biodistribution profiles in the organs/tissues analyzed, and no oral absorption was observed. We conclude that the different components of the AuNPs system, in this case the Au core and citrate surface coating, did not remain intact, resulting in the different distribution profiles observed. A better understanding of the biodistribution profiles of other surface attachments or cargo of AuNPs in relation to the Au core is required to successfully use AuNPs as drug delivery vehicles. View Full-Text
Keywords: gold nanoparticles; dual radiolabeling; biodistribution profiles; Sprague Dawley rats gold nanoparticles; dual radiolabeling; biodistribution profiles; Sprague Dawley rats
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rambanapasi, C.; Barnard, N.; Grobler, A.; Buntting, H.; Sonopo, M.; Jansen, D.; Jordaan, A.; Steyn, H.; Zeevaart, J.R. Dual Radiolabeling as a Technique to Track Nanocarriers: The Case of Gold Nanoparticles. Molecules 2015, 20, 12863-12879.

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