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Molecules 2015, 20(6), 10004-10031; doi:10.3390/molecules200610004

Synthesis and Physicochemical Characterization of the Impurities of Pemetrexed Disodium, an Anticancer Drug

1
Pharmaceutical Research Institute, 8 Rydygiera Street, 01-793 Warsaw, Poland
2
Institute of Organic Chemistry, Polish Academy of Sciences, 44/52 Kasprzaka Street, 01-224 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 30 April 2015 / Revised: 25 May 2015 / Accepted: 26 May 2015 / Published: 29 May 2015
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A physicochemical characterization of the process-related impurities associated with the synthesis of pemetrexed disodium was performed. The possibility of pemetrexed impurities forming has been mentioned in literature, but no study on their structure has been published yet. This paper describes the development of the synthesis methods for these compounds and discusses their structure elucidation on the basis of two-dimensional NMR experiments and MS data. The identification of these impurities should be useful for the quality control during the production of the pemetrexed disodium salt. View Full-Text
Keywords: pemetrexed; impurities; NMR; diastereoisomers pemetrexed; impurities; NMR; diastereoisomers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Michalak, O.; Gruza, M.M.; Witkowska, A.; Bujak, I.; Cmoch, P. Synthesis and Physicochemical Characterization of the Impurities of Pemetrexed Disodium, an Anticancer Drug. Molecules 2015, 20, 10004-10031.

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