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Molecules 2015, 20(5), 9455-9467; doi:10.3390/molecules20059455

Relationship between High-Performance Liquid Chromatography Fingerprints and Uric Acid-Lowering Activities of Cichorium intybus L.

School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China
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Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 26 March 2015 / Accepted: 18 May 2015 / Published: 22 May 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1008 KB, uploaded 22 May 2015]   |  

Abstract

This study aimed to explore the spectrum-effect relationships between high-performance liquid chromatography fingerprints and the uric acid-lowering activities of chicory. Chemical fingerprints of chicory samples from ten different sources were determined by high-performance liquid chromatography, and then investigated by similarity analysis and hierarchical clustering analysis. Pharmacodynamics experiments were conducted in animals to obtain the uric acid-lowering activity information of each chicory sample. The spectrum-effect relationships between chemical fingerprints and the uric acid-lowering activities of chicory were established by canonical correlation analysis. The structures of potential effective peaks were identified by liquid chromatography with tandem mass spectrometry. The results showed that a close correlation existed between the spectrum and effect of chicory. Aesculin, chlorogenic acid, chicoric acid, isochlorogenic acid A/B/C and 13,14-seco-stigma5(6),14(15)-diene-3α-ol might be the main effective constituents. This work provides a general model of the combination of high-performance liquid chromatography and uric acid-lowering activities to study the spectrum-effect relationships of chicory, which can be used to discover the principle components responsible for the bioactivity. View Full-Text
Keywords: chicory; spectrum-effect relationships; uric acid-lowering chicory; spectrum-effect relationships; uric acid-lowering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhu, C.-S.; Zhang, B.; Lin, Z.-J.; Wang, X.-J.; Zhou, Y.; Sun, X.-X.; Xiao, M.-L. Relationship between High-Performance Liquid Chromatography Fingerprints and Uric Acid-Lowering Activities of Cichorium intybus L.. Molecules 2015, 20, 9455-9467.

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