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Molecules 2015, 20(5), 8856-8874; doi:10.3390/molecules20058856

Silver Nanoparticles as Potential Antibacterial Agents

1
Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138 Napoli, Italy
2
Department of Pharmacy, University of Naples Federico II, 80100 Naples, Italy
3
Istituto di Biostrutture e Bioimmagini, CNR, 80100 Napoli, Italy
4
CIRPEB, and DFM, University of Naples Federico II, 80100 Naples, Italy
5
Department of Experimental Medicine, II University of Naples, 80138 Naples, Italy
6
Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra 444602, India
*
Author to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Received: 29 March 2015 / Accepted: 12 May 2015 / Published: 18 May 2015
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Abstract

Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. Advances in nanotechnology have opened new horizons in nanomedicine, allowing the synthesis of nanoparticles that can be assembled into complex architectures. Novel studies and technologies are devoted to understanding the mechanisms of disease for the design of new drugs, but unfortunately infectious diseases continue to be a major health burden worldwide. Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. Currently nanotechnology and nanomaterials are fully integrated in common applications and objects that we use every day. In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. This review aims to summarize the emerging efforts to address current challenges and solutions in the treatment of infectious diseases, particularly the use of nanosilver antimicrobials. View Full-Text
Keywords: AgNPs; antibacterial; resistence; biofilm AgNPs; antibacterial; resistence; biofilm
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Franci, G.; Falanga, A.; Galdiero, S.; Palomba, L.; Rai, M.; Morelli, G.; Galdiero, M. Silver Nanoparticles as Potential Antibacterial Agents. Molecules 2015, 20, 8856-8874.

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