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Molecules 2015, 20(5), 8654-8665; doi:10.3390/molecules20058654

Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants

Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario, Campus Universitario #2, Apartado Postal 669, Chihuahua, Chih. 31125, Mexico
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Academic Editor: Derek J. McPhee
Received: 9 April 2015 / Accepted: 7 May 2015 / Published: 14 May 2015
(This article belongs to the Section Organic Synthesis)
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Abstract

A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antioxidants for the prevention of cardiovascular diseases. View Full-Text
Keywords: benzofuran; antioxidant; palladium benzofuran; antioxidant; palladium
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

López-Frías, G.; Camacho-Dávila, A.A.; Chávez-Flores, D.; Zaragoza-Galán, G.; Ramos-Sánchez, V.H. Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants. Molecules 2015, 20, 8654-8665.

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