Next Article in Journal
Special Issue: Practical Applications of Metal Complexes
Previous Article in Journal
Antinociceptive Activity and Toxicity Evaluation of the Fatty Oil from Plukenetia polyadenia Mull. Arg. (Euphorbiaceae)
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(5), 7940-7950; doi:10.3390/molecules20057940

Effect of Culture Conditions on Metabolite Production of Xylaria sp.

1
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
2
The First College of Clinical Medical Science, China Three Gorges University, Yichang 443002, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 March 2015 / Revised: 26 April 2015 / Accepted: 28 April 2015 / Published: 30 April 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1077 KB, uploaded 30 April 2015]   |  

Abstract

Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated. A shift in the production of five known cytochalasin-type analogues 15 to six new α-pyrone derivatives, xylapyrones A–F (compounds 611), from a solid to a liquid medium was observed. These compounds were identified by analysis of 1D and 2D NMR and HRMS data. Compounds 13 showed moderate cytotoxicity against HepG2 and Caski cancer cell lines with IC50 values ranging from 25 to 63 μM and compounds 411 were found to be inactive, with IC50 values >100 μM. View Full-Text
Keywords: Xylaria sp.; cryptic natural product; cytochalasin; α-pyrone; xylapyrones; cytotoxicity Xylaria sp.; cryptic natural product; cytochalasin; α-pyrone; xylapyrones; cytotoxicity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhang, H.; Deng, Z.; Guo, Z.; Peng, Y.; Huang, N.; He, H.; Tu, X.; Zou, K. Effect of Culture Conditions on Metabolite Production of Xylaria sp.. Molecules 2015, 20, 7940-7950.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top