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Molecules 2015, 20(2), 2922-2930; doi:10.3390/molecules20022922

Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines

1,†
,
2,†
,
2,* and 1,*
1
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Changle West Road 15, Xi'an 710032, China
2
Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Panayiotis Koutentis
Received: 11 December 2014 / Accepted: 30 January 2015 / Published: 11 February 2015
View Full-Text   |   Download PDF [714 KB, uploaded 11 February 2015]   |  

Abstract

Well-defined unnatural dipeptide-alcohols based on a cis-2,5-disubstitued pyrrolidine backbone were synthesized from commercially available starting materials meso-diethyl-2,5-dibromoadipate, (S)-(−)-1-phenylethylamine, and phenylalaninol. The structures of these unnatural dipeptide-alcohols are supported by HRMS, 1H- and 13C-NMR spectroscopy. These unnatural dipeptide-alcohols can act as building blocks for peptidomimetics. View Full-Text
Keywords: cis-2,5-disubstituted pyrrolidine; unnatural dipeptide-alcohol; hydrogenolysis; phenylalaninol cis-2,5-disubstituted pyrrolidine; unnatural dipeptide-alcohol; hydrogenolysis; phenylalaninol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jia, Y.-Y.; Li, X.-Y.; Wang, P.-A.; Wen, A.-D. Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines. Molecules 2015, 20, 2922-2930.

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