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Molecules 2015, 20(2), 2802-2815; doi:10.3390/molecules20022802

Entamoeba histolytica: Adhesins and Lectins in the Trophozoite Surface

Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Dr. Balmis #148, Col. Doctores, C.P. 06726 Mexico, D.F., Mexico
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Author to whom correspondence should be addressed.
Academic Editor: Tzi Bun NG
Received: 16 November 2014 / Accepted: 13 January 2015 / Published: 9 February 2015
(This article belongs to the Special Issue Lectins)
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Abstract

Entamoeba histolytica is the causative agent of amebiasis in humans and is responsible for 100,000 deaths annually, making it the third leading cause of death due to a protozoan parasite. Pathogenesis appears to result from the potent cytotoxic activity of the parasite, which kills host cells within minutes. Although the mechanism is unknown, it is well established to be contact-dependent. The life cycle of the parasite alternates with two forms: the resistant cyst and the invasive trophozoite. The adhesive interactions between the parasite and surface glycoconjugates of host cells, as well as those lining the epithelia, are determinants for invasion of human tissues, for its cytotoxic activity, and finally for the outcome of the disease. In this review we present an overview of the information available on the amebic lectins and adhesins that are responsible of those adhesive interactions and we also refer to their effect on the host immune response. Finally, we present some concluding remarks and perspectives in the field. View Full-Text
Keywords: Entamoeba histolytica; lectins; adhesins; cytotoxicity Entamoeba histolytica; lectins; adhesins; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Aguirre García, M.; Gutiérrez-Kobeh, L.; López Vancell, R. Entamoeba histolytica: Adhesins and Lectins in the Trophozoite Surface. Molecules 2015, 20, 2802-2815.

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