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Molecules 2015, 20(2), 2229-2271; doi:10.3390/molecules20022229

Human Lectins and Their Roles in Viral Infections

School of Life Sciences and Biomedical Research Unit in Gastroenterology, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, UK
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Author to whom correspondence should be addressed.
Academic Editor: Tzi Bun NG
Received: 17 November 2014 / Revised: 21 January 2015 / Accepted: 23 January 2015 / Published: 29 January 2015
(This article belongs to the Special Issue Lectins)
View Full-Text   |   Download PDF [2601 KB, uploaded 29 January 2015]   |  

Abstract

Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that recognise viral pathogen-associated molecular patterns (PAMPs) including viral glycoproteins. In this review we discuss the contribution of soluble and membrane-associated PRRs to immunity against virus pathogens, and the potential role of these molecules in facilitating virus replication. These processes are illustrated with examples of viruses including human immunodeficiency virus (HIV), hepatitis C virus (HCV) and Ebola virus (EBOV). We focus on the structure, function and genetics of the well-characterised C-type lectin mannose-binding lectin, the ficolins, and the membrane-bound CD209 proteins expressed on dendritic cells. The potential for lectin-based antiviral therapies is also discussed. View Full-Text
Keywords: innate immunity; lectin; HIV; hepatitis viruses; therapeutics; mannose binding lectin; ficolin; DC-SIGN innate immunity; lectin; HIV; hepatitis viruses; therapeutics; mannose binding lectin; ficolin; DC-SIGN
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mason, C.P.; Tarr, A.W. Human Lectins and Their Roles in Viral Infections. Molecules 2015, 20, 2229-2271.

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