Next Article in Journal
Phenolic Assesment of Uncaria tomentosa L. (Cat’s Claw): Leaves, Stem, Bark and Wood Extracts
Previous Article in Journal
Short-Term and Sub-Chronic Dietary Exposure to Aspalathin-Enriched Green Rooibos (Aspalathus linearis) Extract Affects Rat Liver Function and Antioxidant Status
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(12), 22691-22702; doi:10.3390/molecules201219876

Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

1
Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania
2
Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timişoara, 6 Carol Telbisz, 300001 Timisoara, Romania
3
Research Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, 300115 Timisoara, Romania
4
Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6 Eotvos Str., H-6720 Szeged, Hungary
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 November 2015 / Revised: 4 December 2015 / Accepted: 7 December 2015 / Published: 18 December 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2263 KB, uploaded 18 December 2015]   |  

Abstract

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid. View Full-Text
Keywords: betulonic acid derivatives; triterpene; thermal analysis; synthesis; biological activity; MTT assay betulonic acid derivatives; triterpene; thermal analysis; synthesis; biological activity; MTT assay
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ledeţi, I.; Avram, Ş.; Bercean, V.; Vlase, G.; Vlase, T.; Ledeţi, A.; Zupko, I.; Mioc, M.; Şuta, L.-M.; Şoica, C.; Dehelean, C. Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives. Molecules 2015, 20, 22691-22702.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top