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Molecules 2015, 20(12), 22691-22702; doi:10.3390/molecules201219876

Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania
Faculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timişoara, 6 Carol Telbisz, 300001 Timisoara, Romania
Research Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, 300115 Timisoara, Romania
Department of Pharmacodynamics and Biopharmacy, University of Szeged, 6 Eotvos Str., H-6720 Szeged, Hungary
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 November 2015 / Revised: 4 December 2015 / Accepted: 7 December 2015 / Published: 18 December 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2263 KB, uploaded 18 December 2015]   |  


Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid. View Full-Text
Keywords: betulonic acid derivatives; triterpene; thermal analysis; synthesis; biological activity; MTT assay betulonic acid derivatives; triterpene; thermal analysis; synthesis; biological activity; MTT assay

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ledeţi, I.; Avram, Ş.; Bercean, V.; Vlase, G.; Vlase, T.; Ledeţi, A.; Zupko, I.; Mioc, M.; Şuta, L.-M.; Şoica, C.; Dehelean, C. Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives. Molecules 2015, 20, 22691-22702.

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