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Molecules 2015, 20(12), 22499-22519; doi:10.3390/molecules201219862

Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Wim Dehaen
Received: 23 November 2015 / Revised: 7 December 2015 / Accepted: 8 December 2015 / Published: 15 December 2015
(This article belongs to the Collection Heterocyclic Compounds)
View Full-Text   |   Download PDF [17734 KB, uploaded 15 December 2015]   |  


An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high. View Full-Text
Keywords: Fe/HCl; reductive cyclization; 4-indolylquinoline; indolylchalcone Fe/HCl; reductive cyclization; 4-indolylquinoline; indolylchalcone

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, W.-C.; Lin, C.-C.; Kavala, V.; Kuo, C.-W.; Huang, C.-Y.; Yao, C.-F. Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl. Molecules 2015, 20, 22499-22519.

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