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Molecules 2015, 20(12), 22445-22453; doi:10.3390/molecules201219801

New Ent-Kaurane-Type Diterpene Glycosides and Benzophenone from Ranunculus muricatus Linn.

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University, Guangzhou 510632, China
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 21 October 2015 / Revised: 16 November 2015 / Accepted: 21 November 2015 / Published: 15 December 2015
(This article belongs to the Section Molecular Diversity)
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Abstract

Two new ent-kaurane diterpene glycosides, ranunculosides A (1) and B (2), and a new benzophenone, ranunculone C (3), were isolated from the aerial part of Ranunculus muricatus Linn. The chemical structures of compounds 13 were established to be (2S)-ent-kauran-2β-ol-15-en-14-O-β-d-glucopyranoside, (2S,4S)-ent-kauran-2β,18-diol-15-en-14-O-β-d-glucopyranoside, and (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxy-phenyl]-2-hydroxylpropanoic acid, respectively, by spectroscopic data and chemical methods. The absolute configuration of 1 was determined by the combinational application of RP-HPLC analysis and Mosher’s method. View Full-Text
Keywords: Ranunculus muricatus; ent-kaurane diterpene; ranunculoside; benzophenone; ranunculone C Ranunculus muricatus; ent-kaurane diterpene; ranunculoside; benzophenone; ranunculone C
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wu, B.-L.; Zou, H.-L.; Qin, F.-M.; Li, H.-Y.; Zhou, G.-X. New Ent-Kaurane-Type Diterpene Glycosides and Benzophenone from Ranunculus muricatus Linn.. Molecules 2015, 20, 22445-22453.

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