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Molecules 2015, 20(12), 21909-21923; doi:10.3390/molecules201219815

Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide

1
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy and Division of Laboratory Medicine, Medical University of Warsaw, 1 Banacha St., Warsaw 02-097, Poland
2
Department of Organic Chemistry, Faculty of Materials Science and Design, Kazimierz Pulaski University of Technology and Humanities in Radom, Ul. Chrobrego 27, Radom 26-600, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 November 2015 / Revised: 23 November 2015 / Accepted: 30 November 2015 / Published: 8 December 2015
(This article belongs to the Section Organic Synthesis)
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Abstract

Polylactide (PLA) represents one of the most promising biomedical polymers due to its biodegradability, bioresorbability and good biocompatibility. This work highlights the synthesis and characterization of PLAs using novel diethylzinc/gallic acid (ZnEt2/GAc) and diethylzinc/propyl gallate (ZnEt2/PGAc) catalytic systems that are safe for human body. The results of the ring-opening polymerization (ROP) of rac-lactide (rac-LA) in the presence of zinc-based catalytic systems have shown that, depending on the reaction conditions, “predominantly isotactic”, disyndiotactic or atactic PLA can be obtained. Therefore, the controlled and stereoselective ROP of rac-LA is discussed in detail in this paper. View Full-Text
Keywords: biomedical polymers; polylactide; ring-opening polymerization; zinc-based catalysts; gallic acid; propyl gallate biomedical polymers; polylactide; ring-opening polymerization; zinc-based catalysts; gallic acid; propyl gallate
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Żółtowska, K.; Piotrowska, U.; Oledzka, E.; Sobczak, M. Efficient Diethylzinc/Gallic Acid and Diethylzinc/Gallic Acid Ester Catalytic Systems for the Ring-Opening Polymerization of rac-Lactide. Molecules 2015, 20, 21909-21923.

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