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Molecules 2015, 20(12), 21658-21671; doi:10.3390/molecules201219797

Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins

1
Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche—Sezione di Chimica e Tecnologie Farmaceutiche—Università degli Studi di Palermo, Via Archirafi 32, Palermo 90123, Italy
2
IEMEST, Istituto Euromediterraneo di Scienza e Tecnologia, Via Emerico Amari, 123, Palermo 90139, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Received: 16 October 2015 / Revised: 19 November 2015 / Accepted: 24 November 2015 / Published: 4 December 2015
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Abstract

The emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis. View Full-Text
Keywords: pyrrolomycins; antibiotic resistance; antibiofilm agents; pyoluteorin; pentabromopseudilin pyrrolomycins; antibiotic resistance; antibiofilm agents; pyoluteorin; pentabromopseudilin
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Cascioferro, S.; Raimondi, M.V.; Cusimano, M.G.; Raffa, D.; Maggio, B.; Daidone, G.; Schillaci, D. Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins. Molecules 2015, 20, 21658-21671.

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