Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins
AbstractThe emergence of antibiotic resistance is currently considered one of the most important global health problem. The continuous onset of multidrug-resistant Gram-positive and Gram-negative bacterial strains limits the clinical efficacy of most of the marketed antibiotics. Therefore, there is an urgent need for new antibiotics. Pyrrolomycins are a class of biologically active compounds that exhibit a broad spectrum of biological activities, including antibacterial, antifungal, anthelmintic, antiproliferative, insecticidal, and acaricidal activities. In this review we focus on the antibacterial activity and antibiofilm activity of pyrrolomycins against Gram-positive and Gram-negative pathogens. Their efficacy, combined in some cases with a low toxicity, confers to these molecules a great potential for the development of new antimicrobial agents to face the antibiotic crisis. View Full-Text
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Cascioferro, S.; Raimondi, M.V.; Cusimano, M.G.; Raffa, D.; Maggio, B.; Daidone, G.; Schillaci, D. Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins. Molecules 2015, 20, 21658-21671.
Cascioferro S, Raimondi MV, Cusimano MG, Raffa D, Maggio B, Daidone G, Schillaci D. Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins. Molecules. 2015; 20(12):21658-21671.Chicago/Turabian Style
Cascioferro, Stella; Raimondi, Maria V.; Cusimano, Maria G.; Raffa, Demetrio; Maggio, Benedetta; Daidone, Giuseppe; Schillaci, Domenico. 2015. "Pharmaceutical Potential of Synthetic and Natural Pyrrolomycins." Molecules 20, no. 12: 21658-21671.