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Molecules 2015, 20(11), 20823-20831; doi:10.3390/molecules201119722

Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito

1
Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-701, Korea
2
Graduate School of Biotechnology and Department of Genetic Engineering, Kyung Hee University, Yongin 446-701, Korea
3
Department of Herbal Crop Research, National Institute of Horicultural and Herbal Science, RDA, Eumseong 369-873, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 4 September 2015 / Revised: 11 November 2015 / Accepted: 13 November 2015 / Published: 23 November 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [567 KB, uploaded 23 November 2015]   |  

Abstract

A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides—adonioside A (1) and adonioside B (6)—as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3). View Full-Text
Keywords: Adonis multiflora; adonioside A; adonioside B; cardenolide; cytotoxic activity Adonis multiflora; adonioside A; adonioside B; cardenolide; cytotoxic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jung, J.-W.; Baek, N.-I.; Hwang-Bo, J.; Lee, S.-S.; Park, J.-H.; Seo, K.-H.; Kwon, J.-H.; Oh, E.-J.; Lee, D.-Y.; Chung, I.-S.; Bang, M.-H. Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito. Molecules 2015, 20, 20823-20831.

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