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Molecules 2015, 20(11), 20741-20776; doi:10.3390/molecules201119714

Current Research on Antiepileptic Compounds

1,†
,
1,†
and
1,2,*
1
Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao 028000, China
2
Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 29 July 2015 / Revised: 3 November 2015 / Accepted: 6 November 2015 / Published: 20 November 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [10832 KB, uploaded 20 November 2015]   |  

Abstract

Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for the development of more effective and safer AEDs. Based on our research work on antiepileptic compounds and other references in recent years, this review covers the reported work on antiepileptic compounds which are classified according to their structures. This review summarized 244 significant anticonvulsant compounds which are classified by functional groups according to the animal model data, although there are some limitations in the data. This review highlights the properties of new compounds endowed with promising antiepileptic properties, which may be proven to be more effective and selective, and possibly free of unwanted side effects. The reviewed compounds represent an interesting possibility to overcome refractory seizures and to reduce the percentage of patients with a poor response to drug therapy. View Full-Text
Keywords: epilepsy; antiepileptic compounds; structure activity relationship epilepsy; antiepileptic compounds; structure activity relationship
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wei, C.-X.; Bian, M.; Gong, G.-H. Current Research on Antiepileptic Compounds. Molecules 2015, 20, 20741-20776.

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