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Molecules 2015, 20(11), 20240-20253; doi:10.3390/molecules201119692

Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley Rats

1
Department of Food Science and Biotechnology, College of Life Science, CHA University, Kyonggi 463-400, Korea
2
Korea Food Research Institute, Kyonggi, Seongnam 463-746, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Christopher W. K. Lam
Received: 18 September 2015 / Revised: 3 November 2015 / Accepted: 5 November 2015 / Published: 10 November 2015
(This article belongs to the Collection Herbal Medicine Research)
View Full-Text   |   Download PDF [2670 KB, uploaded 10 November 2015]   |  

Abstract

Global temperature change causes heat stress related disorders in humans. A constituent of red ginseng has been known the beneficial effect on the resistance to many diseases. However, the mechanism of red ginseng (RG) against heat stress still remains unclear. To determine the effect of RG on heat stress, we examined the effect of the RG on the gene expression profiles in rats subjected to environmental heat stress. We evaluated the transcripts associated with hepatic lipid accumulation and oxidative stress in rats subjected to heat stress. We also analyzed the reactive oxygen species (ROS) contents. Our results suggested RG inhibited heat stress mediated altering mRNA expressions include HSPA1, DEAF1, HMGCR, and FMO1. We also determined RG attenuated fat accumulation in the liver by altering C/EBPβ expression. RG promoted to repress the heat stress mediated hepatic cell death by inhibiting of Bcl-2 expression in rats subjected to heat stress. Moreover, RG administered group during heat stress dramatically decreased the malondialdehyde (MDA) contents and ROS associated genes compared with the control group. Thus, we suggest that RG might influence inhibitory effect on environmental heat stress induced abnormal conditions in humans. View Full-Text
Keywords: red ginseng; herbal medicine; heat environmental stress; lipid peroxidation; lipid accumulation; ginsenoside red ginseng; herbal medicine; heat environmental stress; lipid peroxidation; lipid accumulation; ginsenoside
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MDPI and ACS Style

Kim, K.-J.; Yoon, K.-Y.; Hong, H.-D.; Lee, B.-Y. Role of the Red Ginseng in Defense against the Environmental Heat Stress in Sprague Dawley Rats. Molecules 2015, 20, 20240-20253.

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